Pharmacological agents and transport nanosystems based on plant phospholipids.

Autor: Medvedeva, N., Prozorovskiy, V., Ignatov, D., Druzilovskaya, O., Kudinov, V., Kasatkina, E., Tikhonova, E., Ipatova, O.
Zdroj: Biochemistry (Biokhimiya). Supplemental Series B, Biomedical Chemistry; Jul2015, Vol. 9 Issue 3, p205-216, 12p
Abstrakt: A new generation of plant phosphatidylcholine (PCh)-based pharmacological agents has been developed under academician A.I. Archakov leadership at the Institute of Biomedical Chemistry (IBMC). For their production a unique technology allowing to obtain dry lyophilized phospholipid nanoparticles up to 30 nm was elaborated. The successful practical application of PCh nanoparticles as a drug agent may be illustrated by Phosphogliv (oral and injection formulations). Being developed at IBMC for the treatment of liver diseases, including viral hepatitis, Phosphogliv (currently marketed by the 'Pharmstandard' company) is approved for clinical application in 2000, and is widely used in medical practice. Based on the developed and scaled in IBMC technology of preparation of ultra small size phospholipid nanoparticles without the use of detergents/surfactants and stabilizers another drug preparation, Phospholipovit, exhibiting pronounced hypolipidemic properties has been developed. Recently completed preclinical studies have shown that PCh nanoparticles of 20-30 nm activate reverse cholesterol transport (RCT) and in this context it is more active than well known foreign preparation Essentiale. Phospholipovit is now at the stage of clinical trials (phase 1 completed). PCh was also used as a basis for the development of a transport nanosystem with a particle size of 20-25 nm in diameter and also for incorporation of drug substances from various therapeutic groups. Using several drugs substances as an example, increased bioavailability and specific activity were demonstrated for the formulations equipped with such transport nanosystem. Formulations equipped with the transport nanosystems have been developed for such pharmacological agents as doxorubicin, rifampicin, budesonide, chlorin E6, prednisolone, and others. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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