| Autor: |
Martins, Carla de M., Nascimento, Evandro A. do, de Morais, Sérgio A. L., de Oliveira, Alberto, Chang, Roberto, Cunha, Luís C. S., Martins, Mário M., Martins, Carlos Henrique G., Moraes, Thaís da S., Rodrigues, Paulla V., Silva, Cláudio V. da, de Aquino, Francisco J. T. |
| Předmět: |
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| Zdroj: |
Evidence-based Complementary & Alternative Medicine (eCAM); 4/16/2015, Vol. 2015, p1-9, 9p, 4 Charts |
| Abstrakt: |
Many essential oils (EOs) of different plant species possess interesting antimicrobial effects on buccal microorganisms and cytotoxic properties. EOs of Kielmeyera coriacea Mart. & Zucc. were analyzed by gas chromatography coupled to mass spectrometry (GC-MS). The EO from leaves is rich in sesquiterpenes hydrocarbons and oxygenated sesquiterpenes. The three major compounds identified were germacrene-D (24.2%), (E)-caryophyllene (15.5%), and bicyclogermacrene (11.6%). The inner bark EO is composed mainly of sesquiterpenes hydrocarbons and the major components are alpha-copaene (14.9%) and alpha-(E)-bergamotene (13.0%). The outer bark EO is composed mainly of oxygenated sesquiterpenes and long-chain alkanes, and the major components are alpha-eudesmol (4.2%) and nonacosane (5.8%). The wood EO is mainly composed of long-chain alkanes and fatty acids, and the major components are nonacosane (9.7%) and palmitic acid (16.2%). The inner bark EO showed the strongest antimicrobial activity against the anaerobic bacteria Prevotella nigrescens (minimum inhibitory concentration-MIC of 50 µg mL−1). The outer bark and wood EOs showed MICs of 100 µg mL−1 for all aerobic microorganisms tested. The EOs presented low toxicity to Vero cells. These results suggest that K. coriacea, a Brazilian plant, provide initial evidence of a new and alternative source of substances with medicinal interest. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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