Oxidation of Disulfides to Taurine and Sulfanilic Acid Derivatives.

Autor: Šála, Michal, Dejmek, Milan, Procházková, Eliška, Hřebabecký, Hubert, Rybáček, Jiří, Dračínský, Martin, Novák, Pavel, Rosenbergová, Šárka, Rosenberg, Ivan, Nencka, Radim
Předmět:
Zdroj: Synthesis; 2015, Vol. 47 Issue 17, p2609-2616, 8p
Abstrakt: Taurine (2-aminoethanesulfonic acid) is a representative substructure in biologically active compounds, but can raise difficulties in direct coupling reactions. In this study, the synthesis of taurine-derived sulfonic acids and analogous aromatic sulfonic acids was accomplished by a performic acid promoted oxidation of corresponding symmetrical disulfide precursors. In some of the products, the taurine or sulfanilic acid nitrogen atom is incorporated in a heterocyclic scaffold or part of a peptide bond in dipeptide mimetics. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index