| Abstrakt: |
Objective: To determine the plasma concentration of propofol in surgical patients under general anesthesia, and also to analyze the relationship between actually measured concentrations and predicted concentrations of the target -controlled infusion (TCI), so as to evaluate the effectiveness of the TCI system . Methods: Twenty surgical patients under general anesthesia with American Society of Anesthesiology (ASA ) evaluation scores of ASA 1-ASA2 were enrolled for the study . In the TCI system, the induction concentration of propofol was 6 μg/ml, and the maintenance concentrations of propofol were 2 .8,3 .2,3 .5 and 3 .8 μg/ml, respectively. Propofol concentrations in plasma were detected after medication at various time points by HPLC method. Results: The actually measured concentrations of propofol in plasma both at induction and maintenance stages were higher than those of the TCI. Upon completion of infusion, the actually measured concentrations were lower than those of the TCI. The median performance error (MDPE ) and median absolute performance error (MDAPE) of the TCI system were 6.0% and 6.2%, respectively. Bispectral index, response entropy and state entropy of the patients were obviously affected by anesthesia. Conclusion: The TCI system with the monitoring of anesthetic indicators, could provide reference for clinical medication. [ABSTRACT FROM AUTHOR] |
