Higher Cardiovascular Risk in Common Variable Immunodeficiency and X-Linked Agammaglobulinaemia Patients.
| Autor: | Vieira, Daniele Gonçalves, Costa-Carvalho, Beatriz Tavares, Hix, Sonia, da Silva, Rosangela, Correia, Milena S.G., Sarni, Roseli Oselka Saccardo |
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| Předmět: |
AIDS complications
HEART disease risk factors THERAPEUTIC use of biochemical markers ACADEMIC medical centers AGAMMAGLOBULINEMIA BLOOD testing CHI-squared test STATISTICAL correlation FISHER exact test INFLAMMATION NUTRITION PATIENT monitoring PUBLIC health surveillance RESEARCH funding STATISTICS T-test (Statistics) DATA analysis CROSS-sectional method DATA analysis software DESCRIPTIVE statistics MANN Whitney U Test DISEASE complications GENETICS |
| Zdroj: | Annals of Nutrition & Metabolism; Aug2015, Vol. 66 Issue 4, p237-241, 5p, 3 Charts |
| Abstrakt: | Introduction: Common variable immunodeficiency and X-linked agammaglobulinaemia are primary immunodeficiencies classified as antibody deficiencies, and they both result in hypogammaglobulinaemia. Objective: Evaluate the lipid profile and other cardiovascular risk biomarkers in CVID and XLA patients. Methods: In total, 24 patients and 12 healthy controls matched by age and gender were included in the study. We evaluated anthropometric measurements, and seric total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides (TG), apo A-I, small dense LDL (sdLDL), C-reactive protein (CRP), and tumour necrosis factor alpha (TNF-alpha), myeloperoxidase (MPO), cholesteryl ester transfer protein (CETP), and lecithin cholesterol acyltransferase (LCAT) were assessed. Results: CRP (p = 0.008) and TNF-alpha (p < 0.001) concentrations were significantly higher, whereas HDL-c (p = 0.025) and apo A-I (p = 0.013) levels were significantly lower in patients than in the controls. In the patient group, a negative and significant correlation was observed between HDL-c and TNF-alpha (r = -0.406; p = 0.049) and between HDL-c and TG (r = -0.641; p = 0.001). Conclusion: Common variable immunodeficiency and X-linked agammaglobulinaemia patients presented themselves with increased inflammatory markers associated with a decreased HDL-c and apo A-I levels, which can predispose to a high cardiovascular risk. © 2015 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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