Anti-Parkinsonian Activity of Hemantane on a Model of Hemiparkinsonian Syndrome in Rats.

Autor:	Ivanova, E., Kapitsa, I., Val'dman, E., Voronina, T.
Předmět:	PARKINSONIAN disorders DRUG therapy DOPA DRUG efficacy MEDICATION safety LABORATORY rats THERAPEUTICS
Zdroj:	Bulletin of Experimental Biology & Medicine; Jul2015, Vol. 159 Issue 3, p380-383, 4p
Abstrakt:	Hemantane demonstrated a pronounced antiparkinsonian activity in the model of hemiparkinsonian syndrome provoked in rats by unilateral intracerebral injection of 6-hydroxydopamine, which was comparable to efficacy of levodopa in decreasing the duration of cataleptogenic state and the degree of akinesia of the contralesional forelimb assessed in the cylinder test. In the stepping test, hemantane exerted a long-term effect in contrast to levodopa, which diminished its beneficial action to the treatment day 21. In the swing test, the behavior normalized only by hemantane. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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