DNA methylation level and telomere length as a basis for modeling of the biological aging clock.

Autor: Runov, A., Vonsky, M., Mikhelson, V.
Zdroj: Cell & Tissue Biology; Jul2015, Vol. 9 Issue 4, p261-264, 4p
Abstrakt: Aging is a process defined by a variety of both external and internal factors. A person's biological age determines the extent of bodily deterioration and risk of age-related diseases. Various parameters, including average telomere length and level of DNA methylation, are considered indicators of biological age. We proposed to combine these parameters to create a model suitable to assess human biological age. Application of qPCR for determination of telomere length and MS-HRM for methylation analysis will help to determine parameters of interest quickly and requires a limited set of equipment. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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