Life-threatening bradyarrhythmia with oral phenytoin overdose.

Autor: Srinivasan, Giridharan, Wyawahare, Mukta, Mathen, Pratheesh George, Subrahmanyam, Dharanipragada K.
Předmět:
Zdroj: Journal of Pharmacology & Pharmacotherapeutics; Jul-Sep2015, Vol. 6 Issue 3, p179-181, 3p
Abstrakt: We report a case of a 41-year-old lady, who developed severe hypotension and sinus bradycardia, following oral consumption of 20 g of phenytoin and 500 mg of glibenclamide. She required high dose of inotropes and a temporary transvenous pacer for her hemodynamic instability. This life-threatening cardiotoxicity of phenytoin could have been due to its interaction with sulphonylurea. It is imperative to be aware of drug interactions, due to which, life-threatening cardiovascular manifestations following phenytoin toxicity can occur. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index