Therapeutic drug monitoring of modified release once daily tacrolimus in de novo renal transplant with conversion to a twice daily generic in the stable period.

Autor: Mathew, Binu Susan, Prabha, Ratna, Basu, Gopal, Rajkumar, Pradeep, Tamilarasi, Veerasamy, Fleming, Denise Helen
Předmět:
Zdroj: Journal of Pharmacology & Pharmacotherapeutics; Jul-Sep2015, Vol. 6 Issue 3, p156-159, 4p
Abstrakt: The article focuses on a study related to therapeutic drug monitoring (TDM)of once daily modified release (MR) tacrolimus Advagraf and tacrolimus twice daily PanGraf in renal transplant recipients. Topics discussed include the tacrolimus area under concentration time curve (AUC) being studied, reduction of AUC with the use of PanGraf, pharmacokinetic exposure being different in Advagraf and PanGraf, dose optimization being determined through an AUC while converting to PanGraf.
Databáze: Complementary Index