| Autor: |
Ivachtchenko, A., Yamanushkin, P., Mitkin, O., Kisil, V., Korzinov, O., Vedenskii, V., Leneva, I., Bulanova, E., Bichko, V., Okun', I., Ivashchenko, A., Ivanenkov, Ya. |
| Předmět: |
|
| Zdroj: |
Pharmaceutical Chemistry Journal; Jun2015, Vol. 49 Issue 3, p151-162, 12p |
| Abstrakt: |
Novel substituted 5-hydroxy-2-aminomethyl-1 H-indole-3-carboxylic acids and their derivatives were synthesized. The antiviral properties of these compounds were investigated in relation to bovine viral diarrhea virus (BVDV), hepatitis C virus (HCV), and influenza A/Aichi/2/69 (H3N2) virus. Of the compounds synthesized here, only the 5-hydroxy-2-(dimethylaminomethyl)-1-methyl-6-pyridin-3-yl- and 5-hydroxy-2-(dimethylaminomethyl)-1-methyl-6-fluoro-1 H-indole-3-carboxylic acid ethyl ester hydrochlorides had significant activity against these viruses, these agents not only suppressing the replication of influenza A/Aichi/2/69 (H3N2) virus in cell cultures at micromolar concentrations, but also demonstrating high efficacy, greater than that of Arbidol, in a model of influenza pneumonia in mice infected with influenza A/Aichi/2/69 (H3N2) virus, when given at a dose of 25 mg/kg/day. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
