| Autor: |
Ziani, Fatima Zahra, Kanab, Rajae, Atrech, Loubna, Arifi, Samia, Mellas, Nawfel |
| Předmět: |
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| Zdroj: |
Clinical Cancer Investigation Journal; 2015 Supplement, Vol. 4 Issue S1, pS32-S32, 1/3p |
| Abstrakt: |
Introduction: Gestational trophoblastic tumours (GTT) are a rare disease, but it is characterized by high chemo sensitivity. High risk GTT are defined by a FIGO score superior to 6, they are at high risk of developing drug resistance and so are very unlikely to be cured with single-agent chemotherapy. Consequently, several different multi-agent therapies have been developed. EMA/CO regimen (etoposide, methotrexate, and dactinomycin alternating with cyclophosphamide and vincristine) is the most studied in this situation in the first line. The objective of thid study is to evaluate the efficacy and the tolerance of cisplatin based chemotherapy in high risk gestational trophoblastic tumours in first line. Methods: It is a retrospective study of eight patients presenting a GTT admitted in the Medical Oncology Department of Hassan II University Hospital over the period 2009-2012. Results: The median age of patients was 32 years (range 19-44). The median of FIGO score was 7 (range 7-9). Metastatic sites were lung in four cases and liver in two cases. Six cases had a malignant invasive mole and two cases choriocarcinoma. A chemotherapy based on cisplatin 80 mg/m² at day 1, methotrexate 50 mg/m² at day 1 and etoposide 100 mg/m² at days 1, 2 and 3, a cycle every 3 weeks was administered in six cases. BEP regimen (bleomycin at day 1, 8 and 15, cisplatin 20 mg/m² at days 1 to 5 and etoposide at days 1 to 5, a cycle every 3 weeks) was administered in two cases. Two cycles of chemotherapy was administered after negativation of bHCG. A complete response defined by negativation of bHCG and disappearance of metastasis was obtained in all patients. A median of four cycles was administered (range 3 to 6). After a median follow up of one year no experience of recurrence was noted. Concerning tolerance, four patients had grade 2 vomiting and one patient grade 3 vomiting. Four patients had grade 3 and one patient experienced febrile neutropenia. No renal toxicity or Oto toxicity were noted. Conclusion: Cisplatin based chemotherapy in first line treatment of high risk gestational trophoblastic tumours appear effective but the toxicity was significant. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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