| Autor: |
Naciri, F., Bourhaleb, Z., Ouabdelmoumen, A., Sbai, A., Mezouar, L., Elhfid, M. |
| Předmět: |
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| Zdroj: |
Clinical Cancer Investigation Journal; 2015 Supplement, Vol. 4 Issue S1, pS30-S30, 1/3p |
| Abstrakt: |
Introduction: Breast cancer in men is an uncommon disease, accounting for approximately 1% of all breast cancer cases. The aim of our study is to investigate the epidemiological and clinical aspects, the pathological features and results of treatment of this rare entity in the Eastern Region of Morocco. Materials and Methods: This is a retrospective study conducted at the Oncology Center of Oujda between January 2006 and December 2013. We analyzed the clinical records of male patients with breast cancer. In each case, the following features were studied: age, family history, circumstances of discovery, histological and immunohistochemical data, treatment and the evolutionary profile. Results: 25 cases have been collected over this period (0.5% of all breast cancers). The average age of patients was 62,5ans. 4 patients had a family history of breast cancer (16% of cases). The nodule sub-nipple as circumstance of discovery was the most frequent (68%); 15 patients consulted beyond to 3 months (60%). Mammography ± ultrasound were performed in 19 patients (76%). After staging, five patients had metastatic disease (20%). Twenty-three patients underwent surgical treatment (92% of cases). It was a radical Halsted mastectomy for 19 patients (82.6%) and Patey for 4 patients (17.4%). The mean histological tumor size was 3.5cm. 65% were classified as pT1T2 and 35% pT3T4. The only histological type was invasive ductal carcinoma (100% of cases), grade II (SBR) in 95% of cases. 81% of patients had axillary lymph node involvement. Hormone receptors were positive in 88% and HER2 test negative in 83% of cases. 80% of patients with no metastatic disease had an adjuvant chemotherapy and 90% had an adjuvant radiotherapy and tamoxifen. After a mean of 60 months, 40% of patients with no metastatic disease were kept in control, 40% had a local ± metastatic recurrence after a mean of 33 months and 20% were lost to follow up. Conclusion: Breast cancer in men is rare. The histo-biological profile looks identical to breast cancer of women but locally advanced forms are more frequent. Surgical treatment is based on the Halsted radical mastectomy and adjuvant treatment is similar to that of the woman. The prognosis is related to molecular characteristics, early diagnosis and treatment in a multidisciplinary collaboration. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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