Enantioselective α-Alkylation of Aldehydes by Photoredox Organocatalysis: Rapid Access to Pharmacophore Fragments from β-Cyanoaldehydes.

Autor:	Welin, Eric R., Warkentin, Alexander A., Conrad, Jay C., MacMillan, David W. C.
Předmět:	ALDEHYDES ALKYLATION PHOTOREDUCTION ORGANOCATALYSIS HETEROCYCLIC compounds CHEMICAL synthesis
Zdroj:	Angewandte Chemie; Aug2015, Vol. 127 Issue 33, p9804-9808, 5p
Abstrakt:	The combination of photoredox catalysis and enamine catalysis has enabled the development of an enantioselective α-cyanoalkylation of aldehydes. This synergistic catalysis protocol allows for the coupling of two highly versatile yet orthogonal functionalities, allowing rapid diversification of the oxonitrile products to a wide array of medicinally relevant derivatives and heterocycles. This methodology has also been applied to the total synthesis of the lignan natural product (−)-bursehernin. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.