| Autor: |
Bellini, G, Olivieri, AN, Grandone, A, Alessio, M, Gicchino, MF, Nobili, B, Perrone, L, Maione, S, Miraglia del Giudice, E, Rossi, F |
| Předmět: |
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| Zdroj: |
Scandinavian Journal of Rheumatology; Jul2015, Vol. 44 Issue 4, p284-287, 4p, 1 Chart |
| Abstrakt: |
Objectives: To investigate whether the functional variant Q63R of the cannabinoid 2 (CB2) receptor is associated with susceptibility to oligo/poly-articular juvenile idiopathic arthritis (JIA) and with its clinical features. Method: A total of 171 Italian children with oligoarticular/rheumatoid factor negative poly-articular JIA and 600 healthy controls were enrolled in the study and genotyped. Results: A significant difference in genotype distribution of the CB2 Q63R variant ( CNR2 rs35761398) between oligo/poly-articular JIA patients and controls was found ( p = 0.001). The R63 variant was associated with increased rates of relapse ( p = 0.0001). Conclusions: This study indicates that the CB2 receptor contributes to susceptibility to oligo/polyarticular JIA and to the severity of its clinical course. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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