Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells.

Autor:	Laidlaw, Brian J, Cui, Weiguo, Amezquita, Robert A, Gray, Simon M, Guan, Tianxia, Lu, Yisi, Kobayashi, Yasushi, Flavell, Richard A, Kleinstein, Steven H, Craft, Joe, Kaech, Susan M
Předmět:	INTERLEUKIN-10 T cells INTRACELLULAR pathogens MATURATION (Psychology) LYMPHOCYTIC choriomeningitis virus CD4 antigen
Zdroj:	Nature Immunology; Aug2015, Vol. 16 Issue 8, p871-879, 9p, 7 Graphs
Abstrakt:	Memory CD8+ T cells are critical for host defense upon reexposure to intracellular pathogens. We found that interleukin 10 (IL-10) derived from CD4+ regulatory T cells (Treg cells) was necessary for the maturation of memory CD8+ T cells following acute infection with lymphocytic choriomeningitis virus (LCMV). Treg cell-derived IL-10 was most important during the resolution phase, calming inflammation and the activation state of dendritic cells. Adoptive transfer of IL-10-sufficient Treg cells during the resolution phase 'restored' the maturation of memory CD8+ T cells in IL-10-deficient mice. Our data indicate that Treg cell-derived IL-10 is needed to insulate CD8+ T cells from inflammatory signals, and reveal that the resolution phase of infection is a critical period that influences the quality and function of developing memory CD8+ T cells. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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