| Abstrakt: |
Salmonella typhimurium infection is a significant problem of the poultry industry and public health. More knowledge about various aspects of interaction between salmonella and avian immune system is useful for designing salmonella control programs. The objective of this study was to evaluate the non-specific immune system parameters in native chickens following S. enterica enterica typhimurium infection. For this purpose, 90 one-day-old Iranian native chickens were divided randomly into three groups and reared for 31 days. Experimental infection was performed by oral (10 colony forming units [CFU] of the S. serovar typhimurium) and intracardial (10 CFU of the S. serovar typhimurium) inoculation. Five birds from each group were killed by cervical dislocation at 3, 7, 14, 21 and 28 days post infection (dpi) for postmortem gross lesions. Spleen and caeca were used for bacteriological study and blood samples were taken for measuring other hematological parameters. Systemic infection occurred after 3 dpi, and the spleen of infected chicks cleared after 21 dpi in the oral infected group and after 14 dpi in the intracardial injected group. The infection stimulates synthesis of acute phase proteins (APPs), gangliosides and inflammatory mediators. Gross lesion, bacterial detection, App, gangliosides and inflammatory mediator changes, peaked at 7 dpi. Among the evaluated parameters, total sialic acid (TSA), lipid bound sialic acid (LBSA) and protein bound sialic acid (PBSA) showed the greatest changes, so these factors could be considered as the most sensitive parameters. [ABSTRACT FROM AUTHOR] |
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