Correlation of the hypotonic shock response and extent of shape change with the new Thrombo LUX™.

Autor:	Kraemer, L., Raczat, T., Weiss, D.R., Strobel, J., Eckstein, R., Ringwald, J.
Předmět:	BLOOD platelets MECHANICAL shock measurement BLOOD transfusion HYPOTONIC solutions LIGHT scattering HEALTH outcome assessment
Zdroj:	Vox Sanguinis; Aug2015, Vol. 109 Issue 2, p194-196, 3p, 1 Graph
Abstrakt:	Thrombo LUX ( TLX)-Score was compared with hypotonic shock response ( HSR) and extent of shape change ( ESC) in 99 samples from 42 platelet concentrates. Tests were performed in parallel and duplicate. Mean values for TLX Score, HSR and ESC were 30·3 ± 3·8%, 69·0 ± 12·2% and 23·2 ± 4·9%, respectively. We found no significant correlation between TLX Score and HSR or ESC ( r = −0·158, P = 0·118 and r = −115, P = 0·255, respectively), whereas HSR and ESC correlated significantly ( r = 0·351, P < 0·001). As TLX Score did not show significant correlation with HSR and ESC, the value of TLX for platelet quality testing remains unclear. Studies comparing these parameters with transfusion outcome are needed. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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