LNA and α-L-LNA: Towards Therapeutic Applications.

Autor:	Wengel, Jesper, Vester, Birte, Lundberg, Lars Bo, Douthwaite, Stephen, Sørensen, Mads D., Ravindra Babu, B., Gait, Michael J., Arzumanov, Andrey, Petersen, Michael, Nielsen, Jakob T.
Předmět:	PHARMACEUTICAL chemistry DRUG development THERAPEUTIC use of oligonucleotides OLIGOMERS MONOMERS
Zdroj:	Nucleosides, Nucleotides & Nucleic Acids; May2003, Vol. 22 Issue 5-8, p601-604, 4p
Abstrakt:	LNA and α-L-LNA are promising candidates for the development of efficient oligonucleotide-based therapeutic agents. Here, we report dose-dependent inhibition of HIV-1 Tat-dependent trans activation by a 12-mer chimeric α-L-LNA/DNA oligomer. This oligomer exhibits a dose-dependency similar to that of the corresponding 12-mer chimeric LNA/2′-O-Me-RNA oligomer. In addition, we show that incorporation of α-L-LNA or LNA monomers into each of the two binding arms of a “10–23” DNAzyme markedly increases cleavage of the target RNA. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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