Nuclease-Deficient FEN-1 Blocks Rad51/BRCA1-Mediated Repair and Causes Trinucleotide Repeat Instability.

Autor:	Spiro, Craig, McMurray, Cynthia T.
Předmět:	ENDONUCLEASES DNA repair CELL death HUNTINGTON disease
Zdroj:	Molecular & Cellular Biology; Sep2003, Vol. 23 Issue 17, p6063-6062, 11p, 6 Color Photographs, 2 Black and White Photographs, 6 Diagrams, 2 Charts, 12 Graphs
Abstrakt:	Discusses the role of nuclease-deficient flap endonuclease (FEN)-1 in blocking Rad51/BRCA1-mediated repair. Role in causing trinucleotide repeat instability; Susceptibility of human cells expressing nuclease-defective FEN-1 to cell death; Implications for Huntington's disease management.
Databáze:	Complementary Index
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