Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neurons.

Autor: Holm, Pontus C., Rodriguez, Francisco J., Kresse, Adelheid, Canals, Josep M., Silos-Santiago, Immaculada, Arenas, Ernest
Předmět:
Zdroj: Development (09501991); Aug2003, Vol. 130 Issue 15, p3535, 11p, 1 Color Photograph, 3 Black and White Photographs, 4 Graphs
Abstrakt: Evaluates the role of glial cell-line derived neurotrophic factor and neurotrophins in the development of locus coeruleus (LC) noradrenergic (NA) neurons. Generation of double null mutant mice; Loss of NA LC neurons in the TrkB null mutant mice; Proliferation of cells in the LC.
Databáze: Complementary Index