| Autor: |
Paul, Simon, Bogdanov, Mikhail B., Matson, Wayne R., Metakis, Linda, Jacobs, Jonathan, Beal, M. Flint |
| Předmět: |
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| Zdroj: |
Free Radical Research; May2003, Vol. 37 Issue 5, p499, 4p |
| Abstrakt: |
Mitochondrial toxicity of nucleoside analogues has been proposed to be the etiology of a range of side-effects from antiretroviral therapy of HIV infection. In this study, urinary 8-hydroxy-2′-deoxyguanosine (8OH2′dG), a metabolite of oxidized DNA, was measured to determine if antiretroviral therapy leads to oxidative damage to DNA. A cross-sectional study was carried out measuring urinary 8OH2′dG in three groups of HIV-infected patients: (1) antiretroviral medication naïve, (2) patients on antiretroviral medications without lipodystrophy and (3) patients on antiretroviral medications with lipodystrophy. Twenty-five patients were enrolled in each group. The mean spot urinary 8OH2′dG measurements per mg creatinine for the three groups were: antiretroviral naïve 4.27±0.61 (ng 8OH2′dG/mg creatinine±SEM), on antiretroviral medications without lipodystrophy 2.88±0.26, and on antiretroviral medications with lipodystrophy 3.27±0.30. The differences between the means of the three groups is not statistically significant ( p =0.055), and these results are not significantly different from reported values for healthy controls [A carbon column-based liquid chromatography electrochemical approach to routine 8-hydroxy-2′-deoxyguanosine measurements in urine and other biologic matrices: a one-year evaluation of methods. Free Radical Biology and Medicine 27 (1999) 647-666]. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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