| Autor: |
Liquan Xue, Stephan W. Morris, Carlos Orihuela, Elaine Tuomanen, Xiaoli Gui, Renren Wen, Demin Wang |
| Předmět: |
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| Zdroj: |
Nature Immunology; Sep2003, Vol. 4 Issue 9, p857, 9p |
| Abstrakt: |
Bcl10 is an intracellular protein essential for nuclear factor (NF)-?B activation after lymphocyte antigen receptor stimulation. Using knockout mice, we show that absence of Bcl10 impeded conversion from transitional type 2 to mature follicular B cells and caused substantial decreases in marginal zone and B1 B cells. Bcl10-deficient B cells showed no excessive apoptosis. However, both Bcl10-deficient follicular and marginal zone B cells failed to proliferate normally, although Bcl10-deficient marginal zone B cells uniquely failed to activate NF-?B efficiently after stimulation with lipopolysaccharide. Bcl10-deficient marginal zone B cells did not capture antigens, and Bcl10-deficient (Bcl10-/-) mice failed to initiate humoral responses, leading to an inability to clear blood-borne bacteria. Thus, Bcl10 is essential for the development of all mature B cell subsets. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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