| Autor: |
Richard CS, Phang PT, McLeod RS, Canadian Association of General Surgeons Evidence Based Reviews in Surgery |
| Zdroj: |
Canadian Journal of Surgery; Feb2003, Vol. 46 Issue 1, p54-56, 3p |
| Abstrakt: |
Question: Does the addition of preoperative radiotherapy increase the benefit of total mesorectal excision for rectal cancer? Design: A randomized controlled trial. Setting: A multicentre setting, which included hospitals from The Netherlands, Sweden, Canada and other European locations. Patients: The study included 1861 patients who had histologically confirmed adenocarcinoma of the rectum without evidence of distant metastases and in whom the inferior margin of the tumour was located not farther that 15 cm from the anal verge and below the level of Sl-2. Intervention: Patients were randomly assigned to treatment with preoperative radiation (5 Gy on each of 5 d) followed by total mesorectal excision (n = 897) or to total mesorectal excision alone (n = 908). Main outcome measures: Two main outcomes were measured: overall survival rate and local recurrence. Results: The table shows the results at the 2-year follow-up. Conclusion: Preoperative radiotherapy (short course) with total mesorectal excision significantly decreases the local recurrence rate compared with surgery alone at a median follow-up of 2 years. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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