| Autor: |
Sankilampi U, Honkanen PO, Bloigu A, Herva E, Leinonen M, Sankilampi, U, Honkanen, P O, Bloigu, A, Herva, E, Leinonen, M |
| Zdroj: |
Journal of Infectious Diseases; 1996, Vol. 173 Issue 2, p387-393, 7p |
| Abstrakt: |
Antibody response to 23-valent pneumococcal vaccine was assessed in 350 subjects (131 men, 219 women) aged 65-91 years. IgG antibodies to pneumococcal serotypes 4, 6B, 9V, 14, 19F, and 23F were measured by EIA after blocking of antibodies to cell wall polysaccharide. Antibody concentrations in both pre- and postvaccination sera (mean interval, 35 days) were higher in elderly men than women; in the women, the concentrations decreased significantly with increasing age, but not in the men. Antibody fold increases were good in the elderly, including those > or = 85 years old. The overall percentage of the elderly with antibody concentrations > 1 microgram/mL to the 6 antigens increased by vaccination from 61% to 87%, but in the women > or = 85 years old, only to 75%. Antibody response to 23-valent pneumococcal vaccine was satisfactory in the elderly. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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