| Autor: |
Drexler JF, Luna LK, Stöcker A, Almeida PS, Ribeiro TC, Petersen N, Herzog P, Pedroso C, Huppertz HI, Ribeiro Hda C Jr, Baumgarte S, Drosten C, Drexler, Jan Felix, Luna, Luciano Kleber de Souza, Stöcker, Andreas, Almeida, Patrícia Silva, Ribeiro, Tereza Cristina Medrado, Petersen, Nadine, Herzog, Petra, Pedroso, Célia |
| Zdroj: |
Emerging Infectious Diseases; Sep2008, Vol. 14 Issue 9, p1398-1405, 8p |
| Abstrakt: |
Cardioviruses cause serious disease, mainly in rodents, including diabetes, myocarditis, encephalomyelitis, and multiple sclerosis-like disseminated encephalomyelitis. Recently, a human virus isolate obtained 25 years ago, termed Saffold virus, was sequenced and classified as a cardiovirus. We conducted systematic molecular screening for Saffold-like viruses in 844 fecal samples from patients with gastroenteritis from Germany and Brazil, across all age groups. Six cardioviruses were identified in patients <6 years of age. Viral loads were 283,305-5,044,412,175 copies/g of stool. Co-infections occurred in 4 of 6 children. No evidence for outbreak-like epidemic patterns was found. Phylogenetic analysis identified 3 distinct genetic lineages. Viral protein 1 amino acids were 67.9%-77.7% identical and had a distance of at least 39.4% from known cardioviruses. Because closely related strains were found on 2 continents, global distribution in humans is suspected. Saffold-like viruses may be the first human cardiovirus species to be identified. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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