| Autor: |
Gambardella, Antonio, Manna, Ida, Labate, Angelo, Chifari, Rosanna, Serra, Paolo, Russa, Antonella La, LePiane, Emilio, Cittadella, Rita, Andreoli, Virginia, Sasanelli, Francesco, Zappia, Mario, Aguglia, Umberto, Quattrone, Aldo |
| Předmět: |
|
| Zdroj: |
Epilepsia (Series 4); Sep2003, Vol. 44 Issue 9, p1255, 2p |
| Abstrakt: |
A study illustrated an association between temporal lobe epilepsy (TLE) and low-expression promoter alleles of the prodynorphin gene (PDYN) in familial-risk patients. Furthermore, irrespective of their family history, L-homozygotes had an increased risk of febrile convulsions (FCs) or a more severe phenotype. A second study, however, failed to replicate any of these associations. None of the observed genotype counts deviated significantly from those expected according to Hardy-Weinberg equilibrium. No allelic or genotypic association was found in the sample including either all patients or only familial-risk TLE patients. Moreover, no effect of L-alleles was found on the age at onset, severity of TLE phenotype, or previous FCs. Although PDYN may be a plausible candidate gene for TLE, it does not seem to play a major role in its pathogenesis, in patients with mild non-lesional TLE. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text