| Abstrakt: |
Objective: This report examined the characteristics of subjects interested in binge eating disorder (BED) pharmacotherapy trails who were ineligible for participation. Methods: Data on 2685 potential subjects interested in participating in five different placebo-controlled monotherapy trails of BED were analysed. Results: Of the 2685 potential subjects, 1230 (45.8%) were ineligible because they did not meet entry criteria, 586 (21.8%) were eligible for participation, 531 (19.8%) were not interested in the study and 338 (12.6%) were not contacted. Among the 1230 ineligible candidates, 525 (42.7%) were taking exclusionary psychotropic medication, 305 (24.8%) did not meet specified BED criteria, 157 (12.7%) were out of the required age (n=83) or weight (n=74) range, 212 (17.2%) had prohibited medical (n=78) or psychiatric (n=134) disorders and 31 (2.5%) were participating in weight loss programmes. Discussion: Given the complexity of BED, future pharmacotherapy studies should examine a broader range of subjects, including subjects with subthreshold forms of BED, those with comorbid disorders and elderly subjects. Copyright c 2008 John Wiley & Sons, Ltd and Eating Disorders Association. [ABSTRACT FROM AUTHOR] |
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