| Autor: |
Arababadi MK, Pourfathollah AA, Jafarzadeh A, Hassanshahi G, Mohit M, Hajghani M, Shamsizadeh A |
| Zdroj: |
Laboratory Medicine; Apr2010, Vol. 41 Issue 4, p226-230, 5p |
| Abstrakt: |
Background: The main purpose of this study was to investigate the expression of the CCR5 and the delta32 mutation in its gene on the CD8+ T cells in blood donors suffering from an occult hepatitis B infection (OBI). Methodology: The studied population included 57 OBI HBsAg/anti-HBc+ patients with positive HBV-DNA. Flow cytometric analysis and Gap-PCR was performed to examine the expression of CCR5 on CD8+ T cells and CCR5-delta32 mutations, respectively. Results: Flow cytometric analysis indicated that the number of cells which simultaneously co-express CD8 and CCR5 are decreased significantly in patients; no OBI patients had CCR5-delta32 mutations. Conclusions: Based on the results of this study, it can be concluded that the expression of CCR5 on CD8+ T cells is defected in OBI patients. This may be directly related to the CCR5 gene defect (primary abnormality) or CCR5 expressing inducers (secondary abnormality), such as cytokines. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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