| Autor: |
Khattak MN, Buchfelder M, Kleindienst A, Schöfl C, Kremenevskaja N, Khattak, Muhammad Nasir Khan, Buchfelder, Michael, Kleindienst, Andrea, Schöfl, Christof, Kremenevskaja, Natalia |
| Zdroj: |
Cancer Investigation; Aug2010, Vol. 28 Issue 8, p797-805, 9p |
| Abstrakt: |
The Wnt/ß-catenin signalling pathway is involved in tumorigenesis including endocrine tumors. We investigated the Wnt/ß-catenin pathway's modulation by corticotropin-releasing hormone (CRH) and somatostatin or somatotropin release-inhibiting factor (SRIF) in mouse pituitary AtT-20 corticotroph cells. The Wnt/β-catenin signalling pathway was activated by CRH and inhibited by SRIF. We provide evidence that cAMP/PKA signalling is involved affecting the GSK-3β phosphorylation status at phospho-GSK-3β (Ser9), thereby altering β-catenin degradation downstream. Furthermore, CRH and SRIF showed concordant effects on cell proliferation. Our data demonstrate an important role of the Wnt/β-catenin pathway in the proliferative control of pituitary corticotroph cells and describe a mechanism for its regulation by CRH and SRIF. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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