| Autor: |
Carbonell-Estrany X, Simoes EAF, Fullarton JR, Ferdynus C, Gouyon J, European RSV Risk Factor Study Group |
| Zdroj: |
Journal of Perinatal Medicine; 2010, Vol. 38 Issue 4, p411-417, 7p |
| Abstrakt: |
Background: A model to predict hospitalization due to respiratory syncytial virus (RSV) of infants born at 33- 35 weeks' gestation was developed using seven risk factors from the Spanish FLIP study 'birth ±10 weeks from the beginning of the RSV season', 'birth weight', 'breast fed <=2 months', 'number of siblings >=2 years', 'number of family members with atopy', 'number of family members with wheezing', and 'gender'. The aim of this study was to validate the model using French data. Methods: The FLIP model [predictive accuracy 71%, receiver operating characteristic (ROC) 0.791] was tested against the French data (77 hospitalized infants with RSV born at 33-35 weeks and 154 age-matched controls) using discriminatory function analysis by applying the FLIP coefficients to the French data and by generating the seven variable model from the French data. Results: Applying the FLIP coefficients to the French dataset, the model correctly classified 69% of cases (ROC 0.627). The predictive power increased to 73% (ROC 0.654) when 'number of siblings >=2 years' was substituted for 'number of children at school'. The number needed to treat (NNT) in order to prevent 70% of hospitalizations was 18. The model derived using French data could correctly classify 62% of cases in the French data (ROC 0.658). Conclusions: The model was successfully validated and may potentially optimize immunoprophylaxis in French infants born at 33-35 week's gestation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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