| Autor: |
Farfara D, Trudler D, Segev-Amzaleg N, Galron R, Stein R, Frenkel D |
| Zdroj: |
Annals of Neurology; Jan2011, Vol. 69 Issue 1, p170-180, 11p |
| Abstrakt: |
The cleavage of amyloid precursor protein by [gamma]-secretase is an important aspect of the pathogenesis of Alzheimer's disease. [gamma]-Secretase also cleaves other membrane proteins (eg, Notch), which control cell development and homeostasis. Presenilin 1 and 2 are considered important determinants of the [gamma]-secretase catalytic site. Our aim was to investigate whether [gamma]-secretase can be important for microglial phagocytosis of Alzheimer's disease [beta]-amyloid. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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