| Autor: |
Murat Kaya, Murat Tunç, Talha Özdemir, İrfan Altuntaş |
| Předmět: |
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| Zdroj: |
Graefe's Archive of Clinical & Experimental Ophthalmology; May2003, Vol. 241 Issue 5, p418-422, 5p |
| Abstrakt: |
abstract purpose. to detect the neuroprotective role of nimodipine and dantrolene in n-methyl-d-aspartate (nmda)-induced retinal injury. methods. in this study we used two calcium antagonists which have two different modes of action, nimodipine and dantrolene, to prevent nmda-induced retinal ischemia in guinea pigs. in 40 animals we injected nimodipine (n=10), dantrolene (n=10), a combination of both (n=10) or sterile 0.9% nacl solution as a placebo (n=10) before intravitreal injection of nmda. we enucleated one eye of each animal after 48 hours and performed histopathologic examination. we also measured malondialdehyde (mda) levels in retinal homogenates as a marker of ischemic injury. results. our results indicate that ganglion cells of the retina were preserved mostly by nimodipine, followed by combined nimodipine-dantrolene, and dantrolene respectively. the ganglion cell count was statistically significantly higher in cases where we used calcium antagonists than in the control group (p<0.05). we also found that mda was significantly reduced by calcium antagonists compared to the control group (p<0.05). conclusion. our data show that nimodipine and dantrolene both have potential neuroprotective effects; nimodipine preserved retinal ganglion cells to a greater extent than dantrolene from nmda-induced retinal injury. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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