| Autor: |
Xu B, Feng NH, Tong N, Wang ZD, Zhang W, Wu HF, Hua LX, Xu, Bin, Feng, Ning-Han, Tong, Na, Wang, Zi-Dun, Zhang, Wei, Wu, Hong-Fei, Hua, Lin-Xin |
| Zdroj: |
Medical Oncology; Dec2010, Vol. 27 Issue 4, p1031-1036, 6p |
| Abstrakt: |
Vascular endothelial growth factor (VEGF) is a major driver of physiological and pathological angiogenesis and plays important roles in the etiology and metastasis of cancers. The -460C>T polymorphism in VEGF gene region has been implicated in cancer risk and related to VEGF expression. However, published data remain conflicting. To derive a more precise estimation, a meta-analysis of 5,863 cases and 5,276 controls from 14 published case-control studies was performed. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association. VEGF -460T represented a risk factor for cancers in Asians (OR=1.69, 95% CI: 1.09-2.62) but not in Europeans (OR=0.92, 95% CI: 0.78-1.08). Our meta-analysis showed the evidence that VEGF -460T was associated with increased cancer risk in Asians. Further prospective researches with larger numbers of worldwide participants are expected to validate this result. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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