| Autor: |
Warncke K, Fröhlich-Reiterer EE, Thon A, Hofer SE, Wiemann D, Holl RW, DPV Initiative of the German Working Group for Pediatric Diabetology, Warncke, Katharina, Fröhlich-Reiterer, Elke E, Thon, Angelika, Hofer, Sabine E, Wiemann, Dagobert, Holl, Reinhard W, German BMBF Competence Network for Diabetes Mellitus |
| Zdroj: |
Diabetes Care; Sep2010, Vol. 33 Issue 9, p2010-2012, 3p |
| Abstrakt: |
Objective: To investigate diabetes-specific autoantibodies and additional autoimmune phenomena in a large cohort of young patients with type 1 diabetes.Research Design and Methods: Data from 28,671 patients <30 years with type 1 diabetes from 242 specialized centers in Germany and Austria were analyzed.Results: At least one beta-cell antibody was present in 81.6% of patients. beta-cell-Ab-negative patients were significantly younger at diabetes onset (P < 0.0001). A total of 19.6% had positive thyroid antibodies with female predominance (62%, P < 0.0001). Antibodies to tissue transglutaminase were present in 10.7%, with a significantly longer duration of diabetes (P < 0.0001). Parietal cell antibodies were found in 283 patients, associated with older age (P < 0.001), and adrenal antibodies were present in 94 patients. In 575 patients, at least three different autoimmune phenomena were present.Conclusions: Thyroid autoimmunity and antibodies suggestive for celiac disease are the most prevalent additional immune phenomena in type 1 diabetes. Parietal/adrenal antibodies are rare. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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