| Autor: |
Goh V, Shastry M, Engledow A, Reston J, Wellsted DM, Peck J, Endozo R, Rodriguez-Justo M, Taylor SA, Halligan S, Groves AM, Goh, Vicky, Shastry, Manu, Engledow, Alec, Reston, Jonathan, Wellsted, David M, Peck, Jacqui, Endozo, Raymondo, Rodriguez-Justo, Manuel, Taylor, Stuart A |
| Zdroj: |
European Radiology; Apr2011, Vol. 21 Issue 4, p744-749, 6p |
| Abstrakt: |
Objective: To determine how commercial software platform upgrades impact on derived parameters for colorectal cancer.Materials and Methods: Following ethical approval, 30 patients with suspected colorectal cancer underwent Perfusion CT using integrated 64 detector PET/CT before surgery. Analysis was performed using software based on modified distributed parameter analysis (Perfusion software version 4; Perfusion 4.0), then repeated using the previous version (Perfusion software version 3; Perfusion 3.0). Tumour blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability surface area product (PS) were determined for identical regions-of-interest. Slice-by-slice and 'whole tumour' variance was assessed by Bland-Altman analysis.Results: Mean BF, BV and PS was 20.4%, 59.5%, and 106% higher, and MTT 14.3% shorter for Perfusion 4.0 than Perfusion 3.0. The mean difference (95% limits of agreement) were +13.5 (-44.9 to 72.0), +2.61 (-0.06 to 5.28), -1.23 (-6.83 to 4.36), and +14.2 (-4.43 to 32.8) for BF, BV, MTT and PS respectively. Within subject coefficient of variation was 36.6%, 38.0%, 27.4% and 60.6% for BF, BV, MTT and PS respectively indicating moderate to poor agreement.Conclusion: Software version upgrades of the same software platform may result in significantly different parameter values, requiring adjustments for cross-version comparison. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink