Analysing the response in R2* relaxation rate of intracranial tumours to hyperoxic and hypercapnic respiratory challenges: initial results.

Autor: Müller A, Remmele S, Wenningmann I, Clusmann H, Träber F, Flacke S, König R, Gieseke J, Willinek WA, Schild HH, Mürtz P, Müller, A, Remmele, S, Wenningmann, I, Clusmann, H, Träber, F, Flacke, S, König, R, Gieseke, J, Willinek, W A
Zdroj: European Radiology; Apr2011, Vol. 21 Issue 4, p786-798, 13p
Abstrakt: Objective: To investigate the response in R2* relaxation rate of human intracranial tumours during hyperoxic and hypercapnic respiratory challenges.Methods: In seven patients with different intracranial tumours, cerebral R2* changes during carbogen and CO(2)/air inhalation were monitored at 3 T using a dynamic multigradient-echo sequence of high temporal and spatial resolution. The R2* time series of each voxel was tested for significant change. Regions of interest were analysed with respect to response amplitude and velocity.Results: The tumours showed heterogeneous R2* responses with large interindividual variability. In the 'contrast-enhancing' area of five patients and in the 'non-tumoral' tissue most voxels showed a decrease in R2* for carbogen. For the 'contrast-enhancing' area of two patients hardly any responses were found. In areas of 'necrosis' and perifocal 'oedema' typically voxels with R2* increase and no response were found for both gases. For tissue responding to CO(2)/air, the R2* changes were of the same order of magnitude as those for carbogen. The response kinetic was generally attenuated in tumoral tissue.Conclusion: The spatially resolved determination of R2* changes reveals the individual heterogeneous response characteristic of intracranial human tumours during hyperoxic and hypercapnic respiratory challenges. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz: