| Autor: |
Kiremitçi, Abdurrahman, Dinleyici, Ener Çağrı, Yargıç, Zeynel Abidin, Durmaz, GǼl, Tekin, Neslihan, Aybey, Aşkın Derya, Akşit, Mehmet Arif |
| Zdroj: |
Journal of Pediatric Infection / Çocuk Enfeksiyon Dergisi; Jun2011, Vol. 5 Issue 2, p54-58, 5p |
| Abstrakt: |
Objective: The isolation of extended-spectrum β-lactamase (ESBL) -producing bacteria has increased worldwide. Fecal colonization with ESBL-producing isolates is considered a prerequisite for infection. Material and Methods: We prospectively evaluated the prevalence and risk factors for fecal carriage of ESBL-producing E. coli and Klebsiella spp. in hospitalized and ambulatory children. A total of 464 fecal samples from pediatric patients (270 hospitalized and 194 ambulatory) were collected from a tertiary care center in Turkey during a non-outbreak period. All stool samples were evaluated for ESBL production by the combination disc test and for imipenem susceptibility by the CLSI agar dilution method. Results: Sixty-six (24% of total) hospitalized children (25 with Escherichia coli, 39 with Klebsiella pneumoniae and 2 with Klebsiella oxytoca) and 14 (7.2% of total) ambulatory children (10 with E. coli, 3 with K. pneumoniae and 1 with K. oxytoca) had a positive fecal sample for ESBL-producing microorganisms. All isolates were susceptible to imipenem; however, the MIC values of strains isolated from hospitalized patients were 3-4 fold higher in dilution than were those of strains isolated from ambulatory children. Univariate analyses showed that intensive care unit stay, urinary catheterization, indwelling catheterization, surgical interventions and prior 3rd-generation cephalosporin usage were associated with ESBL positivity for the hospitalized patients. Recent 2nd- or 3rd-generation cephalosporin use was found to be associated with ESBL positivity for the ambulatory children. Conclusion: The increased prevalence and antibiotic resistance of ESBL-producing fecal isolates in asymptomatic hospitalized and ambulatory children highlights the importance of these pathogens for the population. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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