A Natural S-Equol Supplement Alleviates Hot Flushes and Other Menopausal Symptoms in Equol Nonproducing Postmenopausal Japanese Women.
| Autor: | Aso, Takeshi, Uchiyama, Shigeto, Matsumura, Yasuhiro, Taguchi, Makoto, Nozaki, Masahiro, Takamatsu, Kiyoshi, Ishizuka, Bunpei, Kubota, Toshiro, Mizunuma, Hideki, Ohta, Hiroaki |
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THERAPEUTICS
ANALYSIS of covariance DIETARY supplements HEALTH surveys MEDICAL cooperation PLACEBOS QUALITY of life QUESTIONNAIRES RESEARCH RESEARCH funding SCALES (Weighing instruments) WOMEN'S health BODY mass index RANDOMIZED controlled trials VISUAL analog scale BLIND experiment POSTMENOPAUSE HOT flashes DATA analysis software DESCRIPTIVE statistics |
| Zdroj: | Journal of Women's Health (15409996); Jan2012, Vol. 21 Issue 1, p92-100, 9p |
| Abstrakt: | Objective: The objective of this clinical trial was to examine the efficacy of a supplement containing natural S-(−)equol, a daidzein metabolite, in reducing menopausal symptoms. Methods: In this multicenter, double-blind placebo-controlled trial, 160 equol nonproducing, postmenopausal Japanese women who experienced at least 1 hot flush/day were randomly assigned to consume 10 mg/day S-(−)equol ( n=77 women) or placebo ( n=83 women) for 12 weeks. Participants completed a standardized menopausal symptom checklist and rated five common menopause symptoms by a visual analog scale at baseline, week 12, and week 18 (6-week postintervention). Physical, blood, and urine examinations were conducted. One hundred twenty-six women completed the study. Results: At baseline, daily hot flush frequency was 2.9±2.1 for the S-(−)equol group and 3.2±2.4 for the placebo group. After the 12-week intervention, the S-(−)equol group had a greater decrease from baseline in hot flush frequency compared with the placebo group (−1.9±1.8/day, −58.7%, vs. −1.0±2.0/day, −34.5%, p=0.009). The severity of hot flushes and neck or shoulder muscle stiffness significantly decreased in the S-(−)equol group compared with the placebo group. No changes in clinical parameters or serious adverse effects were reported. Conclusions: This is the first trial to show beneficial effects of a 10-mg natural S-(−)equol supplement consumed daily for 12 weeks on major menopausal symptoms, specifically, hot flushes and neck or shoulder muscle stiffness, in postmenopausal Japanese women. This supplement offers a promising alternative for management of menopausal symptoms. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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