| Autor: |
Seki, Yoh-ichi, Inoue, Hiromasa, Nagata, Naoko, Hayashi, Katsuhiko, Fukuyama, Satoru, Matsumoto, Koichiro, Komine, Okiru, Hamano, Shinjiro, Himeno, Kunisuke, Inagaki-Ohara, Kyoko, Cacalano, Nicholas, O'Garra, Anne, Oshida, Tadahiro, Saito, Hirohisa, Johnston, James A., Yoshimura, Akihiko, Kubo, Masato |
| Předmět: |
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| Zdroj: |
Nature Medicine; Aug2003, Vol. 9 Issue 8, p1047, 8p |
| Abstrakt: |
Members of the suppressor of cytokine signaling (SOCS) family are involved in the pathogenesis of many inflammatory diseases. SOCS-3 is predominantly expressed in T-helper type 2 (TH2) cells, but its role in TH2-related allergic diseases remains to be investigated. In this study we provide a strong correlation between SOCS-3 expression and the pathology of asthma and atopic dermatitis, as well as serum IgE levels in allergic human patients. SOCS-3 transgenic mice showed increased TH2 responses and multiple pathological features characteristic of asthma in an airway hypersensitivity model system. In contrast, dominant-negative mutant SOCS-3 transgenic mice, as well as mice with a heterozygous deletion of Socs3, had decreased TH2 development. These data indicate that SOCS-3 has an important role in regulating the onset and maintenance of TH2-mediated allergic immune disease, and suggest that SOCS-3 may be a new therapeutic target for the development of antiallergic drugs. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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