Pulse Wave Velocity as Marker of Preclinical Arterial Disease: Reference Levels in a Uruguayan Population Considering Wave Detection Algorithms, Path Lengths, Aging, and Blood Pressure.

Autor: Farro, Ignacio, Bia, Daniel, Zócalo, Yanina, Torrado, Juan, Farro, Federico, Florio, Lucía, Olascoaga, Alicia, Alallón, Walter, Lluberas, Ricardo, Armentano, Ricardo L.
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Zdroj: International Journal of Hypertension; 2012, p1-10, 10p
Abstrakt: Carotid-femoral pulse wave velocity (PWV) has emerged as the gold standard for non-invasive evaluation of aortic stiffness; absence of standardized methodologies of study and lack of normal and reference values have limited a wider clinical implementation. This work was carried out in a Uruguayan (South American) population in order to characterize normal, reference, and threshold levels of PWV considering normal age-related changes in PWV and the prevailing blood pressure level during the study. A conservative approach was used, and we excluded symptomatic subjects; subjects with history of cardiovascular (CV) disease, diabetes mellitus or renal failure; subjects with traditional CV risk factors (other than age and gender); asymptomatic subjects with atherosclerotic plaques in carotid arteries; patients taking anti-hypertensives or lipid-lowering medications. The included subjects (n = 429) were categorized according to the age decade and the blood pressure levels (at study time). All subjects represented the 'reference population'; the group of subjects with optimal/normal blood pressures levels at study time represented the 'normal population.' Results. Normal and reference PWVlevels were obtained. Differences in PWVlevels and aging-associated changes were obtained. The obtained data could be used to define vascular aging and abnormal or disease-related arterial changes. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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