| Autor: |
Salerno, Michael, Janardhanan, Rajesh, Jiji, Ronny S, Brooks, Jeremy, Adenaw, Nebiyu, Mehta, Bhairav, Yang, Yang, Antkowiak, Patrick, Kramer, Christopher M, Epstein, Frederick H |
| Zdroj: |
Journal of Magnetic Resonance Imaging; Jul2013, Vol. 38 Issue 1, p217-224, 8p |
| Abstrakt: |
Purpose: To develop and validate modified Look-Locker (MOLLI) protocols to generate myocardial T1 maps within clinically acceptable breath-hold durations and to compare partition coefficients (λ) of gadolinium (Gd)-DTPA determined from either bolus injection (BI) or continuous infusion (CI) techniques.Materials and Methods: T1 mapping was performed in phantoms and in 10 volunteers on a 1.5T scanner using the standard (3-3-5) MOLLI technique and two MOLLI schemes with shorter breath-hold durations. Imaging was performed precontrast and every 5 minutes following a bolus of 0.1 mmol/kg Gd-DTPA and a 15-minute delayed continuous infusion of 0.001 mmol/kg Gd-DTPA until equilibrium T1 in the myocardium was achieved to enable direct comparison of T1 relaxation times between techniques and λ's between the BI and CI methods.Results: There was good agreement of T1 values between the 3-3-5 standard MOLLI protocol and the modified 3-5 MOLLI protocol in both phantom studies over a range of heart rates and in human subjects. Both MOLLI protocols produced similar measurements of λ using both the BI and CI methods.Conclusion: A reduced breath-hold MOLLI T1 mapping protocol combined with the BI method can accurately characterize T1 and λ in clinically applicable breath-hold durations without requiring a long equilibrium phase infusion. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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