Impact of age on myocardial uptake of ¹²³I-mIBG in older adult subjects without coronary heart disease.

Autor: Jacobson, Arnold F, Chen, Ji, Verdes, Liudmilla, Folks, Russell D, Manatunga, Daya N, Garcia, Ernest V
Zdroj: Journal of Nuclear Cardiology; Jun2013, Vol. 20 Issue 3, p406-414, 9p
Abstrakt: Background: The purpose of this study was to examine the relationship between myocardial uptake of (123)I-mIBG and age in older normal adult subjects.Methods: 94 subjects (age 29-82, mean 58.5) without coronary heart disease were studied. All subjects underwent early and delayed planar and 4-hour SPECT (123)I-mIBG imaging. (123)I-mIBG uptake was quantified as heart/mediastinum ratio on planar images (H/M p) and on SPECT images (H/M s) reconstructed by filtered backprojection, ordered subsets-expectation maximization (OSEM), and OSEM with compensation for collimator septal penetration (DSP). Relationships between age and (123)I-mIBG uptake were examined by correlation analysis, t-tests, and analysis of variance.Results: There was no significant correlation between age and H/M p, reflecting comparable increases in activity in the two regions of interest with age. Results on SPECT analyses were comparable, with no significant correlation between age and H/M s. Using DSP, (123)I-mIBG H/M s was significantly higher in subjects ≥70 of age compared with younger subjects.Conclusions: Both cardiac and background uptake of (123)I-mIBG increase with age in older subjects without coronary heart disease, resulting in stability of H/M results (planar and SPECT). This study suggests that prognostic analyses of quantitative (123)I-mIBG uptake in patients with heart disease do not require adjustment for patient age. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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