| Autor: |
Ryb, Gabriel E., Dischinger, Patricia C., Auman, Kimberly M., Kufera, Joseph A., Cooper, Carnell C., Mackenzie, Colin F., Kane, Robert L. |
| Zdroj: |
Brain Injury; Oct2014, Vol. 28 Issue 11, p1430-1435, 6p |
| Abstrakt: |
Objective: To determine the usefulness of S-100 β, a marker for central nervous system damage, in the prediction of long-term outcomes after mild traumatic brain injury (MTBI) Hypothesis: Mid- and long-term outcomes of MTBI (i.e. 3, 6 and 12 months post-injury and return-to-work or school (RTWS)) may be predicted based on pre-injury and injury factors as well as S-100 β. Methods: MTBI subjects without abnormal brain computed tomography requiring intervention, focal neurological deficits, seizures, amnesia > 24 hours and severe or multiple injuries were recruited at a level I trauma centre. Admission S-100 β measurements and baseline Concussion Symptom Checklist were obtained. Symptoms and RTWS were re-assessed at follow-up visits (3-10 days and 3, 6 and 12 months). Outcomes included number of symptoms and RTWS at follow-up. Chi-square tests, linear and logistic regression models were used and p < 0.05 was considered statistically significant. Results: One hundred and fifty of 180 study subjects had S-100 β results. Eleven per cent were unable to RTWS at 12 months. S-100 β levels were not associated with post-concussive symptomatology at follow-up. In addition, no association was found between S-100 β levels and RTWS. Conclusion: Amongst MTBI patients, S-100 β levels are not associated with prolonged post-concussive syndrome or the inability to RTWS. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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