Extension of the CD4+Foxp3+CD25−/low regulatory T-cell subpopulation in type 1 diabetes mellitus.

Autor: Zóka, András, Barna, Gábor, Somogyi, Anikó, Műzes, Györgyi, Oláh, Ágnes, Al-Aissa, Zahra, Hadarits, Orsolya, Kiss, Katalin, Firneisz, Gábor
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Zdroj: Autoimmunity; Aug2015, Vol. 48 Issue 5, p289-297, 9p
Abstrakt: Regulatory T-cells (Treg) have a crucial role in limiting physiologic autoreactivity. Foxp3 is a master regulator transcription factor of Treg differentiation and active Treg cells express high levels of IL-2 receptor α-chain (CD25). The aim of our study was to assess the key markers of Treg cell function in type 1 diabetic (T1DM) and control subjects by flow cytometry. The proportion of CD25−/low cells among CD4+Foxp3+ Treg cells was higher in T1DM patients that might suggest a shifted proportion of the incomplete/reserve and the fully active (CD4+Foxp3+CD25+) Treg cell subpopulations in T1DM, similarly to other Th1-mediated autoimmune diseases. In addition to the decreased expression of CD25 and CTLA-4 in T1DM patients, a positive correlation was observed between the CD25 expression on CD4+ and the CTLA-4 expression in CD8− T-lymphocytes both in the T1DM and in the healthy control group. Our results suggest an impaired balance of CD25+ and CD25−/low Treg cells in T1DM which might reflect a decreased late phase peripheral Treg activation even in patients with a mean disease duration of more than a decade. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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