| Autor: |
Adams, B. T., Niccoli, S., Chowdhury, M. A., Esarik, A. N. K., Lees, S. J., Rempel, B. P., Phenix, C. P. |
| Předmět: |
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| Zdroj: |
Chemical Communications; 7/21/2015, Vol. 51 Issue 57, p11390-11393, 4p |
| Abstrakt: |
β-Glucocerebrosidase deficiency leads to Gaucher disease and is a potential marker of Parkinson's disease. We have identified N-octyl conduritol aziridine as a potent and specific covalent inactivator of GBA1 in living cells. This compound is a promising lead towards a positron emission tomography probe intended to image GBA1 activity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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