| Autor: |
Valente, Michael, Baey, Camille, Louche, Pauline, Dutertre, Charles ‐ Antoine, Vimeux, Lene, Marañón, Concepción, Hosmalin, Anne, Feuillet, Vincent |
| Zdroj: |
European Journal of Immunology; Aug2014, Vol. 44 Issue 8, p2274-2286, 13p |
| Abstrakt: |
Apoptotic cells represent an important source of self-antigens and their engulfment by dendritic cells (DCs) is usually considered to be related to tolerance induction. We report here an unexpectedly high level of human CD4+ T-cell proliferation induced by autologous DCs loaded with autologous apoptotic cells, due to the activation of more than 10% of naive CD4+ T cells. This proliferation is not due to an increase in the costimulatory capacity of DCs, but is dependent on apoptotic cell-associated material processed through an endo-lysosomal pathway and presented on DC MHC class II molecules. Autologous CD4+ T cells stimulated with apoptotic cell-loaded DCs exhibit suppressive capacities. However, in the presence of bacterial lipopolysaccharide, apoptotic cell-loaded DCs induce the generation of IL-17-producing cells. Thus, apoptotic cell engulfment by DCs may lead to increased autologous responses, initially generating CD4+ T cells with suppressive capacities able to differentiate into Th17 cells in the presence of a bacterial danger signal such as LPS. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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