| Autor: |
CHUN-WEI XU, GANG WANG, WU-LONG WANG, WEN-BIN GAO, CHUAN-JUN HAN, JING-SHAN GAO, LI-YING ZHANG, YANG LI, LIN WANG, YU-PING ZHANG, YU-WANG TIAN, DONG-DONG QI |
| Předmět: |
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| Zdroj: |
Experimental & Therapeutic Medicine; 2015, Vol. 9 Issue 6, p2151-2154, 4p |
| Abstrakt: |
This study aimed to investigate the association of the mRNA expression of the echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion gene with that of thymidylate synthase (TYMS) in non-small cell lung cancer (NSCLC) tissues. Quantitative polymerase chain reaction was used to detect the expression of EML4-ALK fusion gene and TYMS mRNA in 257 cases of NSCLC. The positive rate of EML4-ALK fusion gene was 4.28% in the NSCLC tissues (11/257), and was higher in nonsmokers than in smokers (P<0.05); TYMS mRNA expression was detected in 63.42% (163/257) of cases. An association of the EML4-ALK fusion gene with TYMS expression was detected; a low expression level of TYMS mRNA was observed more frequently when the EML4-ALK fusion gene was present than when it was not detected (P<0.05). In conclusion, patients positive for the EML4-ALK fusion gene in NSCLC tissues are likely to have a low expression level of TYMS, and may benefit from the first-line chemotherapy drug pemetrexed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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