Inhalation Administration of the Sesquiterpenoid Aristolen-1(10)-en-9-ol from Nardostachys chinensis Has a Sedative Effect via the GABAergic System.
Autor: | Hiroaki Takemoto, Michiho Ito, Yoshihisa Asada, Yoshinori Kobayashi |
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Předmět: |
ANIMAL experimentation
AROMATHERAPY BIOLOGICAL models CAFFEINE DIAZEPAM FLUMAZENIL GABA GAS chromatography HUMAN locomotion MASS spectrometry MICE MOLECULAR structure MOTOR ability PENTOBARBITAL PLANT roots SLEEP STATISTICS T-test (Statistics) TERPENES DATA analysis DATA analysis software DESCRIPTIVE statistics INHALATION administration ONE-way analysis of variance |
Zdroj: | Planta Medica; 2015, Vol. 81 Issue 5, p343-347, 5p |
Abstrakt: | Spikenard, the dried roots of Nardostachys chinensis, contains sesquiterpenoids and is widely used as an herbal tranquilizer. We previously demonstrated that spikenard vapor showed a sedative effect when administered by inhalation, and we identified hydrocarbon sesquiterpenoids as active components. Here we investigated the other components that contribute to the effects of spikenard. Six oxygenated sesquiterpenoids, including aristolane- and guaiane-types, were isolated from an acetone extract of spikenard. We evaluated the sedative activities of these oxygenated compounds using an inhalation administration method in a caffeine-treated excitatory mouse model. We identified aristolen-1(10)-en-9-ol and patchouli alcohol as highly effective sedative components. These compounds inhibited locomotion in mice by approximately 60% at a dose of 300 μg/cage. In addition, aristolen-1(10)-en-9-ol prolonged pentobarbital-induced sleep to the same extent as 1 mg/kg diazepam. This effect completely disappeared with the administration of the GABA |
Databáze: | Complementary Index |
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