Activation of Metabotropic Glutamate 5 and NMDA Receptors Underlies the Induction of Persistent Bursting and Associated Long-Lasting Changes in CA3 Recurrent Connections.

Autor: Stoop, Ron, Conquet, Francois, Zuber, Benoit, Voronin, Leon L., Pralong, Etienne
Předmět:
Zdroj: Journal of Neuroscience; 7/2/2003, Vol. 23 Issue 13, p5634, 11p, 3 Diagrams, 2 Charts, 4 Graphs
Abstrakt: Presents a study that described the induction and expression mechanisms of a persistent bursting activity in a horizontal slice preparation of the rat limbic system that includes the ventral part of the hippocampus and the entorhinal cortex. Role of bicuculline-mediated disinhibition in persistent interictal-like bursting in the system; Assessment of the function of antagonists of metabotropic glutamate 5 and N-methyl-D-asparte receptors in the induction of persistent bursting and changes to synaptic strength; Suggestions with regard to potential synaptic mechanisms by which the hippocampus switches to a persistent interictal bursting mode.
Databáze: Complementary Index