The coordinated action of the MVB pathway and autophagy ensures cell survival during starvation.

Autor: Müller, Martin, Schmidt, Oliver, Weys, Sabine, Teis, David, Angelova, Mihaela, Trajanoski, Zlatko, Faserl, Klaus, Kremser, Leopold, Lindner, Herbert, Pfaffenwimmer, Thaddäus, Kraft, Claudine, Dalik, Thomas
Předmět:
Zdroj: eLife; 2015, p1-45, 53p
Abstrakt: The article talks about the degradation and recycling of cellular components. It was shown how selective and non-selective lysosomal protein degradation pathways cooperate to ensure cell survival upon nutrient limitation. A quantitative analysis of starvation induced proteome remodeling in yeast reveals comprehensive changes. Different integral plasma membrane proteins undergo endocytosis and degradation in vacuoles via the multivesicular body (MVB) pathway.
Databáze: Complementary Index